Gerrit Hoekstra - Solution Architect - is currently available for long-term consultancy contracts anywhere in the world.
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Large MySQL databases
... don't work very well using the MyISAM table type. Corruptions and system lock-ups are a-plenty when you have MyISAM tables with more than 1,000,000 records. The only reason you would want to use MyISAM tables is to use the full-text searching functionality, and this feature is only marginally better than using the SQL 'like' statement.
If you are hosting millions of records and need any text-searching capabillity, then your data is probably worth more than the system itself. So go for a proper, but paid-for, RDBMS like Oracle, which also has excellent full-text searching capability. "Don't spoil the boat for a ha'penny's worth of tar" as they say.